World Heritage Sites Assignment Essay Example

World Heritage Sites Assignment Essay Example World Heritage Sites Assignment Essay World Heritage Sites Assignment Essay Australia was the seventh country to approve the convention, in 1974. In Australia, the federal government is responsible for the nomination of World Heritage sites. However, governments do not decide whether a site in their country is inscribed on the World Heritage List. That decision is made by the World Heritage Committee, a group of elected representatives of 21 of the States Parties based at UNESCO headquarters in Paris. What is the difference between a cultural site and a natural site? The difference between a cultural site and a natural site is Cultural heritage sites are man- made sites which reflect the culture of our human ancestors like the Pyramids of Egypt or the Great Wall of China. Natural heritage sites are sites that is created by natural forces and reflects the natural wonders like the Grand Canyon or the Great Barrier Reef. 2. Location and Map Location of Hyde Park Barracks on world map Location of Hyde park Barracks on a local map 3. Site Information Hyde Park Barracks Information The Hyde Park Barracks are where the convicts from the First Fleet lived. It is now a popular place for tourists and locals to go because it is extremely interesting to see how the convicts lived and went about their daily lives. What is special about the Hyde Park Barracks? What I think is special about the Hyde park Barracks is that it is part Of our history as a nation. If we were to destroy it, we would destroy part of our history as Australians. Why was it given World Heritage Status? Think it was given World Heritage Status because if we destroyed it we would to be able to replace it and that would be to destroy part of our history, part of us. Also it would be getting rid of an interesting tourist attraction. 4. Site Management How is the site currently managed? The site is managed by the Historic Houses Trust of New South Wales as a museum open to the public for a small fee. Are there any problems associated with tourism or environmental damage?

African Geography and Growth Essay Example | Topics and Well Written Essays - 1500 words

African Geography and Growth - Essay Example The geography of Africa has to a large extent shaped the kind of economic opportunities available for the African countries and, thus, impacted on the economic development of the continent in general. The interaction between human and physical geography within the framework of economic development has been a major factor which is shaping the direction and rate of Africa’s economic development. This essay gives a critical analysis and discussion of the importance of geography in the economic growth of Africa, including the tragic economic challenges that the continent is experiencing. The essay also presents a discussion of the policies which would have to be put in place to safe Africa from the challenges it is facing which are hampering its growth. Africa’s physical geography, such as climate, has been described as the causes of its minimal economic growth. However, Collier (2007, p. 6) argues that there are geographic factors which act to divide Africa instead of unif ying it. These are said to be the most significant factors which are derailing the economic growth of the continent. To begin with, Africa is an expansive continent. Regardless of this, the nations within the continent and its economic regions are characterized by low income. This is explained by the fact that the natural resources within Africa are not evenly distributed. Some regions have an abundance of natural resources while in some regions of the continent, the resources are very scarce. This has contributed to the uneven economic growth within the continent with most of the continent’s regions registering minimal growth as compare to other parts of the world, such as Asia and Europe, as illustrated in figure 1 below. Figure 1: Comparative Per Capita Growth The physical geography of Africa is very enormous. Bloom and Sachs (1998, p. 207) point out that even if Africa is a large continent, it has been divided into many countries. For this reason, most of the countries wi thin the continent are landlocked. The divisions of countries within Africa have a result caused nations to be divided into those landlocked states which are rich in resources and those which have scarce resources. Moreover, some countries are coastal and rich in resources while others are costal but lack adequate resources. These four categories define the economies of Africa in terms of its physical geography. Those states which have scarcity of resources whether coastal or landlocked are lagging behind in the economic development. Because these two categories of nations are the majority within the continent, Africa’s growth in generally slow as compared to other regions. The landlocked states within Africa lack competitiveness in export and import trade. Lack of competitiveness has also affected the coastal countries. Naude (2004, p. 821) explains that the differences between the resource rich African states are not significant. This is the case whether the resource rich s tates are landlocked or coastal. It is because of the divisions within African states that the competitiveness in the export and import business has been derailed and thus making the content to have a tragic growth level within its economy. However, costal states in Africa participate in export trade but the landlocked countries are prevented from economic interaction with the world markets. The distribution of the African population is even unlike other developing regions such as Asia in which a majority of the population lives within the costal countries. Even though the trend of economic growth in Africa is generally parallel to that of the global economy, Africa

Hanover-Bates Chemical Corporation Case Study Example | Topics and Well Written Essays - 500 words

Hanover-Bates Chemical Corporation - Case Study Example District 1, 2 and 7 performances got little profits as they surpassed their gross profit quote a little (Spiro, et. al, 2008). The performance of northeast district as compared to other districts is constantly low. Other districts performed better than the set target or a little low, while northeast district performed very low. The sale of the northeast district is high, but profits are low if it is accessed in comparison with northeast central (Spiro, et. al, 2008). So, in totality, northeast district is continuously performing low as compared with other districts. Jim Sprague is quite less experienced as the new sales manager of the northeast district. However, the company’s management has trust in his skills. Hank Carver, an experienced and appreciative sales representative is interested to quit his job. The northeast district has poor performance and is unable to meet the gross profit quote. The district is not capable take benefit of potential future accounts. Their sales representative pay expenses are higher as compared to other districts. The sales representatives of northeast district have elevated own selling operating expenses. Northeast district is short of paying attention to major and medium ranged accounts (Spiro, et. al, 2008). Management’s role in improving poor performance in the northeast district is very crucial. The management should support Jim in his task by appointing supporting experienced assistant. There should be a biyearly analysis of the district in comparison with other districts. There should be incentives for outclass performers to motivate sales reps. The management should be revise its standards for the poor performing districts. Jim Sprague should install a monitoring system for the evaluation of expenses related to sales representatives (Spiro, et. al, 2008). He should conduct meetings to inform the sales reps about their elevated salaries in comparison to the sales reps of other districts and

Wet Granulation Advantages And Disadvantages Biology Essay

Wet Granulation Advantages And Disadvantages Biology Essay In this lab three different sets of tablets were produced i.e soft, medium and hard using different processes which mainly included i.e Direct Compression Vs Wet Massing ,different excipients which included (Lactose Vs Calcium Phosphate) and different binders which included (PVP Vs Klucel). Once all the tablets were produced by the above mentioned varying processes, excipients and binders they were studied and compared to see how they would influence a range of tablet testing parameters such as uniformity of weight, friability, crushing strength disintegration time. Introduction: A tablet is perhaps the oldest and the most common pharmaceutical dosage form. Its popularity is due to its convince in the administration of the drug without the help or supervision of a health care practitioner, thus providing patients freedom and a very cost effective means of providing a reproducible medication. A tablet seldom consists of only the active ingredient. In fact , a tablet represents a mixture of one or more active ingredients with a number of inactive ingredients or excipients. There are many reasons for formulating a tablet product with excipients, ranging from management of small dosage amounts of active ingredients to esthetic resons of colour and shape of a product. However, the most fundamental and critical objective of a tablet product is to provide/deliver the active ingredient accurately and reproducibly. Therefore, from this perspective, a tablet is now commonly considered as a drug delivery device (Ahmed, 2000). However all tablets are made by compressing a particulate solid between two punches in a die of a tablet press. For an active ingredient to be transformed into tablets of satisfactory quality , the formulation must have three essential attributes. First, the formulation must flow into the die space of the tablet press sufficiently rapidly and in a reproductible manner Second, the particles in the formulation must cohere when subject to a compressing force, and that coherence should remain after the compressive has been removed. Third after the compression event is complete, it must be possible for the tablet to be removed from the press without damage to either the tablet or the press. Very few active ingredients possess all three of these essentials and some posses none of them. Hence some preliminary treatment is almost invariably necessary. Methods of Tablet Manufactures: There are three main methods of tablet manufacture designed to confer the above mentioned essential attributes to a tablet formulation. Wet granulation and direct compression are the most important, with dry granulation (also termed as precompression or slugging) used in some circumstances. Fig shows the processes of wet granulation and direct compression broken down into their constituent stages. The relative simplicity of the direct compression process is immediately apparent. Ease of removal of the tablet from the press is, in theory at least, readily achieved. Friction occurs between the tablet and the die and punches of the press, which can be overcome by including a lubricant in the formulation. Hence every formulation, irrespective of the method of manufacture, will include a lubricant . This will usually be a metallic salt of a fatty acid such as magnesium stearate. The two other prerequisites-flow and cohesion-can only be achieved by more elaborate technique and are in fact the reasons why wet dry granulation processes were devised. As part of its complexity, wet granulation involves the addition of a liquid (usually water), followed by its removal, normally by evaporation. In addition to the energy requirements of this drying process, the presence of water might bring about hydrolysis of the active ingredients, which will be exacerbated at the elevated temperatures used for drying. If a major component of the formulation such as the diluents were to possess the necessary degree of fluidity and compressibility, granulation would be unnecessary. This is the basis of direct compression method of tablet manufacture. Wet Granulation: Advantages and Disadvantages: The wet granulation process is the traditional method of manufacture and is frequently used in the pharmaceutical industry. Expertise in wet granulation is widely available, as in the required equipment. The process improves flow and cohesion reduces dust and cross contamination and permits the handling of powder blends without loss of homogeneity. Though it has been practiced for many years and therefore may be perceived as an old fashioned process., it must be borne in mind that the wet franulation process has itself undergone a transformation in recent decades. High-speed mixer-granulators, fluidized bed granulation and drying and an ever increasing use of automation have served to make wet granulation a much more efficient and economic process than it once was( Marinelli, 2009). Nevertheless, the wet granulation process still retains many inherent disadvantages. Problems include choice and method of addition of the binder and the effect of drying time and temperature on drug stability and its distribution within the solid mass. Direct Compression Process: Advantages and Disadvantages The most striking feature of the direct compression process is its simplicity and hence economy. Less equipment is required and the number of stages in the process, each of which will require validation, is greatly reduced. There are also lower labour costs, reduced processing time and lower power consumption. On top of that since direct compression is a dry procedure therefore there would be no need for a drying stage. Thus, exposure to water and the elevated temperatures needed to remove that water are avoided, resulting in a decreased risk of deterioration of the active ingredient. A further advantage of DC is that tablets disintegrate into their primary particles rather than granular aggregates. The resultant increase in surface area available for dissolution should result in faster drug release. On the other hand talking about disadvantages, the primary limitation on the use of direct compression is that it depends on the fluidity and compressibility of tablet diluents. Therefor e it cannot be used for low potency, high dose active ingredients, where the inclusion of sufficient diluents in the formulation to permit direct compression would lead to unacceptably large tablets. Thus, active ingredients such as paracetamol and aspirin do not tend themselves to the DC process. However, as stated earlier, such ingredients are often available in pregranulated form (Holm, 2009) Thus considering the different ways to produce tablet it is also important to mention here that there has also been an increased emphasis in developing tablets that provide controlled disintegration/release process of the active ingredient.. These tablets are hence known by different names such as slow,extended, controlled, sustained or delayed release tablets to reflect their drug release characteristics. These modified drug release products provide further convenience to patients by reduced frequency of drug administration, thus increasing the chance of compliance as well. However for establishing the quality of a tablet product, the fundamentals remain the same i.e to ascertain that the product delivers the intended active ingredient in an accurate and reproducible manner. Therefore, tablet testing can be broadly divided into three aspects or categories: Confirmation of the nature of the active ingredient and the product ( Identity, quantity, impurities, integrity etc) Establishing pharmaceutical availability of the active moiety both in vitro and in vivo in humans and if required also in animals. Establishing stability profiles to achieve shelf life. Testing of nature of the tablet products: As a consequence one seeks to establish whether the tablets are within specifications, for example the nature of the active ingredients (identification) expected amount (assay) purity (related compounds) and uniformity of the amount of drug from tablet to tablet (uniformity of dosage units). Commonly these testing procedures are described in pharmacopeias under a specific name. In addition to these tests some other tests such as friability, hardness, disintegration etc are also conducted and will be described as below Uniformity of Dosage Units (B.P Pharmacopoeial Tests) This test is conducted to establish consistency in the content of active ingredient from tablet to tablet. There are generally two approaches taken in establishing this: weight variation or content uniformity. If the active ingredient represents not less than 50% weight of the tablet and greater than 50 mg, then one may establish uniformity of dosage units using the weight variation method. A sample of 10 tablets are weighed individually and results of these weighing are recorded. In the case of the content uniformity approach, a sample of 10 tablets are individually analyzed using the analytical method described under the assay procedure. It is mandatory to use content uniformity for tablets with less than 50 mg of active ingredient and/ or representing less than 50% total mass of the tablets. The content uniformity approach is preferred over the weight variation approach as it more precisely reflects the variation of the active ingredient from tablet to tablet. The required specifi cation for this test is that uniformity of dosage unit should be within a range of 85%-115% with a relative standard deviation of less than or equal to 6% (Holm, 2009) Friability ( Non B.P Pharmacopoeial Test) This test is intended to determine, under defined conditions, the friability of uncoated tablets, the phenomenon whereby tablet surfaces are damaged and/or show evidence of lamination or breakage when subjected to mechanical shock or attrition. Commercially available apparatuses known as friabilators are used for the test. Basically, it consists of a drum with diameter between 283mm and 291mm and having width of 36 mm-40 mm, made of transparent plastic material The drum is attached to the horizontal axis of a device that rotates at 25_1 rpm. The tablets are tumbled at each turn of the drum by a curve projection with an inside radius of 75.5 mm-85.5mm that extends from middle of the drum to outer wall. Thus, at each turn, the tablets roll or slide and fall onto the drum wall or onto each other. Usually, a sample of 10 tablets are tested at a time, unless tablet weight is 0.65 g or less, where 20 tablets are tested. After 100 turns, the tablet samples are evaluated by weighing. If the reduction in the total mass of the tablets is more than 1%, the tablets fail the friability test. Generally, the test is done once. If cracked, cleaved, or broken tablets are obvious, then the sample also fails the test (Marinelli, 2009). Hardness Testing ( Non B.P Pharmacopoeial Test) A tablet requires a certain amount of mechanical strength to withstand the shocks of handling in its manufacturing, packing, shipping, and dispensing. As discussed before, hardness and friability are most common measures used to evaluate tablet strength. The need for testing hardness or crushing strength, in addition to friability, may be explained with an analogy that friability determines how fragile a tablet is. If a tablet is more fragile than expected, then the friability test will detect its substandard quality. However, on the other hand, if the tablets are more robust than desired, a friability test would not detect this deficiency. It is the tablet hardness test that will detect the deficiency (Holm, 2009) Disintegration Test (B.P Pharmacopoeial Tests) A disintegration test is a test to establish how fast a tablet disintegrates into aggregates and/or finer particles. The test assumes that if product disintegrates within a short period of time, such as within 5 min, then the drug would be released as expected and one should not anticipate a problem in the quality of a drug product. Although this test is in use for some products in pharmacopeias, its use is generally diminishing in favor of drug dissolution testing (Holm, 2009) Materials Methods: Please refer to the Pharmaceutics Handbook for MPharm Year2 4.0 ) Results Discussion: A fundamental quality attribute for all pharmaceutical preparations is the requirement for a constant dose of drug between individual tablets. In practice, small variations between individual preparations are accepted and the limits for this variation are defined as standards in pharmacopoeias. For tablets, uniformity of dose or dose variation is tested in two separate tests: uniformity of weight and uniformity of active ingredient. These either reflect indirectly or measure directly the amount of drug substance in the tablet. Uniformity of active ingredient: The uniformity of active ingredient is carried out by ensuring a constant dose of drug between individual tablets. Traditionally, dose variation between tablets is tested in two separate tests; 1- Weight uniformity 2- Content uniformity If the drug forms greater part of the tablet, any variation in the tablet weight obviously indicates a variation in the active ingredient. (Weight uniformity test) If the drug is potent (USP specifies 50 mg of the active ingredient or less), the excipients form the greater part of the tablet weight and the correlation between the tablet weight and amount of the active ingredient can be poor, in this case another test (Content uniformity) must be performed (Holm, 2009) In this lab report the weight uniformity test was carried out (which is one of BP requirements) and the following results were obtained. The below table also shows the maximum and minimum percentage error. Table 4.1: Shows the calculated values for CV% along with maximum and minimum % error for various tablets produced by different processes, binders and excipients. Method Excipient Binder Mean / mg Range / mg % Error    CV% Min Max Min Max Direct Compression Lactose 169 164 173 2.95 2.36 1.7 Direct Compression Calcium Phosphate 146 141 148 3.42 1.36 1.5 Wet Massing Lactose PVP 122 120 125 1.63 2.45 1.4 Wet Massing Calcium Phosphate PVP 175 172 179 1.71 2.20 1.2 Wet Massing Lactose Klucel 118 116 119 1.69 0.84 0.9 Wet Massing Calcium Phosphate Klucel 149 142 154 4.69 3.35 2.88 Thus by the help of the above table 4.1 it can be clearly seen that all the tablets produced by different processes, different binders and different excipients are within the percentage max and min error show values below 6% of CV% thus all of them have passed the weight uniformity test. Different Binders: Binders are the substances which are added either dry or in wet- form to form granules or to form cohesive compacts for directly compressed tablets. An ideal binder should have good binding properties, as determined by compressibility under pressure, high plasticity, low elasticity and small particle size. Small particle size facilitates even distribution of the binder through the inter-particulate void spaces in a tablet. Uniform binder distribution in the tablet results in decreased pore structure and subsequent enhancement in tablet crushing strength. To reduce friability, a binder with highly plastic properties (high deformability) is essential. A further requirement for a good binder is low hygroscopicity. Excessive uptake of moisture (greater than 5 percent) or high moisture content can lead to instability and sticking during production (Summers, 2002) There are many excipients used as binders in the direct compression; these include hydroxypropylcellulose (HPC), methylcellulose (MC), povidone (PVP), hydroxypropylmethylcellulose (HPMC), and starches and their derivatives, such as pregelatinized and granulated starches. These polymers differ in their physico-chemical, mechanical and morphological characteristics. For direct compression, studies suggest highly compactable, plastic, fine particle size binders facilitate compression of drugs at relatively low filler-to-drug ratios, therefore representing ideal properties for tablet binders(Summers, 2002) The two different binders that were used in this lab were PVP Klucel XPF. In order to study the effects of different binders the following two figs will be used. Fig one represents the friability disintegration time Vs Hardness for tablets produced by wet massing with PVP as a binder and Lactose as a filler. Fig 4.1) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Lactose) binder (PVP) Friability : 1.05 % Hardness: 3.75 Kp Disintegration Time: 2.12 decimal mins The above figure represents the friability, Disintegration time and Hradness for a tablet produced the process of wet massing in the presence of lactose (as an excipient) and PVP as a binder. The value of friability as percentage drops from 2% to about 0.75 % as the hardness increases. This is because as friability is the ability to form fines or fragments of the original tablet and since the hardness of the tablet is increasing therefore consequently less fragmentation of the tablet would occur/ take place. On the other hand however the values for disintegration time augments from 0 to 4.5 with an increase in the value of hardness. This is due to the fact that compacts develop mechanical strength by creation of a surface bonding area between particles. This is mainly achieved by irreversible particle deformation that flattens initial asperity. The decrease of particle surface roughness enables molecular forces to act. Thus, the indentation hardness can be considered as that portion of the compression pressure that contributes to the formation of interparticulate contacts. Accordingly (Hiestand, 2000) proposed the tablet hardness to correspond to the magnitude of the bonding active compression pressure considering these arguments for the strengthening mechanism of tablets, the direct link between hardness and bonding points seems to be a reasonable theoretical approach. Fig 4.2) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Lactose) binder (Klucel) Optimum Hardness: 6.5 Kp Optimum Friability: 2.70% Optimum Disintegration Time: 3.45 (time/ decimal mins) The above figure represents the friability, Disintegration time and Hardness for a tablet produced the process of wet massing in the presence of lactose (as an excipient) and Klucel as a binder. From the above figure 4.2 it can be seen that with increased hardness of the tablet the value of the friability drops down. Whereas a direct relationship can be seen between the hardness and disintegration time. Comparing the above two fig 4.1 and 4.2 , it can be seen that fig 4.2 has an optimum hardness value of 6.5 whereas that for fig 4.1 has a hardness value of 3.75 .In a similar fashion there is a difference in the values of optimum disintegration time too with fig 4.2 showing higher disintegration time in comparison to that showed by fig 4.1.This difference in the optimum hardness value is due to the difference of binders. From the obtained results it can be seen that using Klucel results in optimum hardness much high in comparison to when PVP is used. But the value for optimum friability is less i.e 1.05% when PVP is used in comparison to Klucel (friability value is 2.70%). In a similar fashion the values for disintegration time is less for tablets produced by PVP whereas it is high for tablets produced by Klucel . Hence from the results obtained above the PVP seems to be a superior binder in comparison to Klucel in terms of lower friability and less disintegration time period. Fig 4.3) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Calcium Phosphate ) binder (PVP) Optimum Hardness: 5.8 Kp Optimum Friability: 0.78% Optimum Disintegration Time: 0.38 (time/ decimal mins) Fig 4.4) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Calcium Phosphate ) binder (Klucel) Optimum Hardness: 1.4 Kp Optimum Friability: 0% Optimum Disintegration Time: 0.2 (time/ decimal mins) From fig 4.4 it can be seen that the friability behaves quite unexpectedly with increasing hardness. Normally with the tablets, the increase of compression force causes a reduction of friability. The value of friability falls down from 2.75 % to 0 but then starts to rise again as the hardness augments to 5 Kp. One of the possible explanation for this trend could be due to the fact that When the compression force increases, the particles deform plastically and the tablets become harder and less friable But at higher compression forces the friability of the tablets seemed to increase again although the crushing strength remain stable. This could be explained by some fragmentation of the system. Thus again by the help of the above two fig 4.3 and 4.8 it can be clearly seen that the results obtained in this comparison case are opposite to the results obtained by the help of the fig 4.1 4.2. PVP yielded tablets which have higher optimum hardness in comparison to those produced by Klucel. A similar case is with friability and disintegration time too. Thus in this case Klucel stands out to be a superior binder (with respect to low friability and disintegration value). However literarure (Ahmed, 2000) shows that K90 grade for PVP used in this lab (more viscous in comparison to that of Klucel) should produce harder granules. Furthermore using a high grade for PVP like K90 , which is highly viscous, would result in higher dissolution time and hence high disintegration time, which would also consequence in the production of harder tablets. Thus the harder the tablet are the lower friability they would have. Klucel on other hand is less viscous, therefore is will produce softer granules hence softer tablets (therefore low disintegration time and high friability of the tablets will be observed) But this case is not entirely true in all circumstances, as it depends on the grades of the binders used. For example some (Summers, 2002) shows that some grades of Klucel exhibits a unique combination of thermoplasticity with organic solvent or aqueous solubility, allowing tough tablet preparation using many different formulation techniques. Furthermore a tougher binder with a high degree of plastic flow provides better friability performance. In addition, such binder characteristics allow a tableting process to run at a higher compaction speed without capping process. Beyond unmatched tablet hardness and friability, benefits of tableting with Klucel include: à ¢Ã¢â€š ¬Ã‚ ¢ Lower compression and ejection forces; and à ¢Ã¢â€š ¬Ã‚ ¢ Reduction or elimination of tablet capping. On top of this (Boyle) also shows that Klucel can be used at lower use levels to yield superior tablets, compared to tablets with higher binders levels of HPMC, MC, PVP (Grade K 70) and pre-gelatinized starch. (Aqualon) also stated that High-dose acetaminophen formulations using lower levels of poorer binder like PVP (K70) resulted in poorer formulations due to capping. Furthermore, Klucel (Low Grade) has low viscosity due to which it has much lower (almost twice less) the dissolution time in comparison to that for PVP (grade K70). This has a direct impact on disintegration. Thus the lower the dissolution time is, the faster it will disintegrate (hence will show fast effect) (Marinelli, 2009) Different Excipients: In this lab only two different types of excipients were used i.e Lactose and Calcium Phosphate Fig 4.5) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Lactose) binder (PVP) Optimum Hardness: 3.78Kp Optimum Friability: 1.1 % Optimum Disintegration Time: 2.15 (time/ decimal mins) Fig 4.6) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Calcium Phosphate ) binder (PVP) Optimum Hardness: 5.80 Kp Optimum Friability: 0.78% Optimum Disintegration Time: 0.38 (time/ decimal mins) By the help of the fig 4.5 and 4.6 it can be clearly seen that the value of optimum hardness (for lactose) 3.78 Kp is quite low in comparison to the value of optimum hardness 5.80Kp for tablets which had calcium phosphate as main excipient. However the same figures also show that lactose has a higher value for friability (1.1%) and disintegration time (2.15 decimal min) in comparison to those showed by calcium phosphate. (Friability 0.78%) and disintegration (0.38 time decimal mins). This difference is due to the fact that lactose is more compressible than calcium phosphate and hence requires less amount of compressible force (as this is what the obtained data suggests). However in real time it has been proposed by (Marinelli, 2009) that calcium phosphate has higher density, hence higher compressibility. Therefore in such a case low compression weight would be required to produce hard tablets with less friability. Whereas in case of lactose it has been suggested that it has lower tap ped density hence poor compressibility. This suggests that at lower pressures it will be elastic and therefore a higher compression weight will be required to produce hard tablets with lesser/lower friability. Fig 4.7) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Lactose) binder (Klucel) Optimum Hardness: 6.5 Kp Optimum Friability: 2.70% Optimum Disintegration Time: 3.45 (time/ decimal mins) Fig 4.8) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (calcium phosphate) binder (Klucel) Optimum Hardness: 1.4 Kp Optimum Friability: 0% Optimum Disintegration Time: 0.2 (time/ decimal mins) Thus by the help of the figures 4.7 and 4.8 it can be seen that the results obtained for lactose and calcium phosphate are opposite to the results obtained in figures 4.5 and 4.6. Fig 4.7 and 4.8 show that tablets produced using lactose had high optimum hardness to those produced by calcium phosphate. In a similar fashion the values for friability and disintegration time for tablets produced using lactose were high in comparison to those produced by calcium phosphate. However literature (Marinelli, 2009) suggests that lactose is also more water soluble than calcium phosphate therefore it will dissolve and provide a pathway for diffusion of drug and erosion of matrix, leading to a faster (lower dinintegration time) release of drug from matrix tablets (in comparison to calcium phosphate). Different Processess: The two different sets of processes used in this lab were direct compression and wet massing Fig 4.9) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Lactose) binder (PVP) Optimum Hardness: 3.78 Kp Optimum Friability: 1.1 % Optimum Disintegration Time: 2.15 (time/ decimal mins) Fig 4.10 ) Shows relationship between friability, hardness disintegration time for tablet produced by the process (Direct Compression) excipient (Lactose) Optimum Hardness: 3.00 Kp Optimum Friability: 0.480 % Optimum Disintegration Time: 0.15 (time/ decimal mins) Thus by the help of the figure 4.8 and 4.9 it can be clearly seen that tablets produced by direct compression show lower optimum hardness, lower value for friability and lower value for disintegration time. Wet massing on the other hand results in tablets formed with high optimum hardness value, high friability value and high disintegration time. It is also worth mentioning at this stage that direct compression process required DC lactose and calcium phosphate of higher grades (Direct compression formulations require good flow in order to maintain proper weight uniformity) whereas low grade regular lactose and calcium phosphate were used for wet massing (during wet massing low grade excipients were used however the granules produced could have been affected by sieving) With regards to wet massing, it is generally agreed that there will exist an optimum range of granule sizes for a particular formulation, and therefore certain generalizations are worthy to note here. Within limits, smaller granules will lead to higher and more uniform tablet weight and higher tablet crushing strength, with subsequent longer disintegration time and reduced friability. The strength of granules has also been shown to influence the tensile strength of the tablets prepared from them, with stronger granules leading, in general to harder tablets (Marinelli, 2009). Conclusion: Fianlly to sum up everything, it was seen in this lab that all the set of tablets produced (hard, soft medium) via different processes or by different excipients or binders , all of them passed the uniformity of weight test. Concerning binders, in this lab PVP seem to stand superior to Klucel (however this might not always be the case). Regarding excipients both lactose and calcium phosphate could be used. As , calcium phosphate has higher density, hence higher compressibility. Therefore in such a case low compression weight would be required to produce hard tablets with less friability. Whereas in case of lactose it has lower tapped density hence poor compressibility. This suggests that at lower pressures it will be elastic and therefore a higher compression weight will be required to produce hard tablets with lesser/lower friability. Lastly , both DC and wet massing were used to produce tablets however tablets produced by DC had shorter disintegration time in compariso n to those produced by wet massing.

Comparing Poe’s Fall of the House of Usher and Taylor’s Venus, Cupid, F

Edgar Allan Poe’s The Fall of the House of Usher and Peter Taylor’s Venus, Cupid, Folly and Time Various authors develop their stories using gothic themes and characterizations of this type to lay the foundation for their desired reader response. Although Edgar Allan Poe’s â€Å"The Fall of the House of Usher† and Peter Taylor’s â€Å"Venus, Cupid, Folly and Time† are two completely different narratives, both of these stories share a commonality of gothic text representations. The stories take slightly different paths, with Poe’s signifying traditional gothic literature and Taylor approaching his story in a more contemporary manner. Gothic texts are typically characterized by a horrifying and haunting mood, in a world of isolation and despair. Most stories also include some type of supernatural events and/or superstitious aspects. Specifically, vampires, villains, heroes and heroines, and mysterious architecture are standard in a gothic text. Depending upon the author, a gothic text can also take on violent and grotesque attributes. As an overall outlook, â€Å"gothic literature is an outlet for the ancient fears of humanity in an age of reason† (Sacred-Texts). Following closely to this type of literature, Edgar Allan Poe uses a gloomy setting, isolation, and supernatural occurrences throughout â€Å"The Fall of the House of Usher†. From the onset of the story, it is apparent that Poe is employing a gothic theme upon his work. The narrator’s portrayal of the home of his longtime friend, Roderick Usher was as follows, â€Å"I looked upon the scene before me – upon the bleak walls – upon the vacant eye-like windows – upon a few rank sedges – and upon a few white trunks of decayed trees† (Poe, 75). T... ... Poe’s â€Å"The Fall of the House of Usher†, they both can be classified collectively under gothic literature. In other words, although these stories exhibit two completely different plots, it has been found that they have matching frameworks. Works Cited Bronzino, Agnolo. Venus, Cupid, Folly and Time. 27 Mar. 2003 arthp/bio/b/bronzino/biograph.html>. Oates, Joyce Carol. â€Å"Realism of Distance, Realism of Immediacy [Review of The Collected Stories]. Critical Essays on Peter Taylor. Ed. Hubert H. McAlexander. New York: G. K. Hall & Company, 1993. Sacred-Texts: Gothic. 3 Apr 2003 . Taylor, Peter. â€Å"Venus, Cupid, Folly and Time†. The Literature of the American South: A Norton Anthology. Ed. William L. Andrews. New York: W. W. Norton & Company, 1998. PID 8308 1 Marlow Engl. 12 Sect. 24

Training audit

Training Needs Identification: Does the organization have and regularly use a systematic, ongoing training needs assessment process, using either a task analysis or a strategic needs assessment method, to Identify specific knowledge, skills, attitudes, and/or behaviors needing Improvement? Yes: After the training Is complete the trainer then gives each trainee an evaluation and asks for them to return in within a week so that they can gain feedback that has been thought about and eased.This also gives them a chance to use the training on the job to see how it goes when you apply the training. 2. Interactive Training: Does training engage the adult learner interactively, whether in an instructor-led classroom environment, self-paced, or blended training delivery, so that knowledge, skills, attitudes, and behavioral change has a greater opportunity to occur?Yes: The training takes place in a classroom whit a trainer that teaches with examples that apply to the lesson as well as activit ies. These help the trainee to understand what they to know and in some ways see how o apply In within their Job before they are In the position to do so. These examples and actively are eased when the feedback from trainees come In. This helps the trainer to keep the classes understood without confusion later. 3.Qualified Trainers and Content Providers: Whether performed by In-house training staff, internal subject matter experts, or external content providers and/or trainers, has a training professional reviewed and approved the qualifications and training materials of all providers to ensure that they will produce a high quality training experience? Yes: The trainer met with focus groups, met with supervisors, observed, and met with other HARD directors while to do the research for this training class. After the research she met with a committee to review and asses the design and delivery.This helps bring in many ideas and different viewpoints to see what may make it better befor e it Is implemented. She then met with vendors to help make the final changes to the training. The managers are required to attend the first session so that they are able to learn and support the trainee as well. 4. Demonstrated Management Support: Is management clearly committed to supporting the training effort? Is there clear evidence that reinforces this assumption? Yes: The managers are to attend the first training session so that they may support the trainee and help them through not only the trainee but to help and show the trainee the support.This helps them to learn what how a manger supports their employees. 5. Evaluation Processes: Are evaluation processes in place and consistently used? Is action taken once evaluation data is collected and analyzed? Yes: Each trainee is to fill out an evaluation and return it within a week of the completion of the training. This gives the trainee efficiently amount of time to fill it out accurately. When it Is returned then the trainer r eads what was written and asses once again. This information gives them the chance to change the things that needs Improvement and to know what Is being obtained correctly.This will Improve the training and bring updates as they are needed. 6. Training Database: Does a training database track targeted and actual employee participation in training programs and other vital training information? Are training professionals, and managers? No: This training does not track the participation of the trainees, however they do have sessions after the training to gather information from the managers. The trainer also monitors the trainees as the training happens. There are reports that are generated with the evaluation that the trainees fill out and the sessions with the managers after the training.

The Poor Condition Of Native Americans - 1184 Words

Many factors have contributed to the abysmal condition of Native Americans in the United States. Two of which had the most impact have been poverty and alcoholism. There are many possible reasons why Native American’s were introduced to alcohol. For instance, their religious practice incorporated alcohol to be able to achieve a transcendent experience. It was not escape from reality that Native Americans sought, but more about fulfillment and discovery of oneself. However, Native Americans were uneducated of how potent alcohol was and what was to come from it being abused by the uneducated, and younger generations. Unfortunately, Native Americans have played a more ambiguous role on proliferating and facilitating the spread of alcohol throughout their communities. Alcohol has led to many health conditions in Native Americans, including kidney failure, and blindness. These health conditions have also led to diabetes, and with little hope from loss of land, Natives Americans st ill to this day live in poverty. Alcohol was introduced to Native Americans in the early 1700’s by European colonists. Most Native Americans could not even obtain alcohol, unless given through trade. That was until in Southwest America a beverage known as Tesvino, made from fermented corn was created and used during special rituals. Other groups such as the Pimos and Papago’s joined and created alcohol from a cactus called Saguro and used it for rituals to create rain. Alcohol was originally initiatedShow MoreRelatedThe Reservation Land For Native Americans980 Words   |  4 PagesChief Justice John Marshall started Native Americans along the slippery slope to poverty when he established a federal doctrine that assigns the government as trustees of Indian affairs. 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